|
The purpose of this study was to access the effectiveness of single 2gm dose of Tinidazole a dertivative of imidazole, in 49 patients suffering from trichomonas vaginalis vaginitis. The aim of this study can be summarized as follows; 1. The inverstigate the safety and tolerance of tinidazole. 2. To determine the optimal dose and duration of therapy on trichomonas vaginalis vaginitis with tinidazole. In all patients the following laboratory tests were carried out ; SGOT, SGPT, alkaline phosphatase serum bilirubin, total and differential white cell count, and BUN for evaluation of drug toxicity. At the same time any side effect was observed. Results; In all patients and their husbands, tinidazole 2gm was administered at one time by mouth only, and wet smear and culture were conducted on 1wk and 4wks later for assesing the evidence of cure. 1. Side effects were appeared 11 cases (22.4%) such as abdominal discomfort, anorexia, dry mouth, verigo, and headache. But they were mild or moderate. 2. Toxicity ; only 2 cases (4.1%) were showed SGOT level increasing on post treatment 1wk, but they were returned normal level on post-treatment 4wks 3. Clinical symptoms and signs were imporved within post-treatment 1wk in 95%. 4. Cure rate ; post treatment 1wk ; 98% post treatment 4wks ; 92%
|